Naked Mole Rat Proteosomes Discovered to be Longevity Clue

Naked mole rats are a unique rodent that have lifespans of over 30 years, more than 10 fold the lifespan of typical rodents.

Recently the genome of the naked mole rat has been sequenced, and researchers continue to work extensively with the animal to discover reasons for its profound longevity.

Indeed any learnings gleaned from this animal could lead to advances in human longevity.

New research is a breakthrough of sorts, it reveals an important ingredient for why the animal live so long.

Proteosomes are cellular organelles or machines that function to break down and recycle damaged proteins within cells.  As cells live proteins are created and then damaged through oxidative stress.  Damaged proteins for one thing cause cells to dysfunction.  They also may aggregate into clumps which can damage or kill the cell.  Protein damage is a major underlying cause of aging.

It is important for cells to detect and destroy damaged proteins.  They do so through the ubiquitin proteasome system which tags defective proteins with ubiquitin molecules and then degrades them in the proteasomes.

In the current stud the researchers compared the activity and composition of the proteasomes of naked mode rats to those of  regular mice.

They discovered the naked mole rats “had significantly higher chymotrypsin-like (ChT-L) activity and a two-fold increase in trypsin-like (T-L) in both whole lysates as well as cytosolic fractions.”

They also found “the 20S proteasome was more active in the longer-lived species and that 26S proteasome was both more active and more populous,” in the naked mole rats and “that both 19S subunits and immunoproteasome catalytic subunits are present in greater amounts in the naked mole-rat suggesting that the observed higher specific activity may be due to the greater proportion of immunoproteasomes in livers of healthy young adults.”

Taken together these findings prove “proteasomes in this species are primed for the efficient removal of stress-damaged proteins.”

“Further characterization of the naked mole-rat proteasome and its regulation could lead to important insights on how the cells in these animals handle increased stress and protein damage to maintain a longer health in their tissues and ultimately a longer life,” they conclude.

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14 Responses to “Naked Mole Rat Proteosomes Discovered to be Longevity Clue”

  1. [...] Image credits: extremelongevity.net [...]

  2. | says:

    [...] alt="" width="605" height="491" /></p> <p>Image credits: <a href="http://extremelongevity.net/2012/05/08/naked-mole-rat-proteosomes-discovered-to-be-longevity-clue/&quot; rel="nofollow" target="_blank">extremelongevity.net</a></p> <h2>Irrawaddy [...]

  3. [...] This creature has a lot of characteristics that make it very important to human beings.  For one it is resistant to cancer.  They also live up to 28 years, which is unheard of in mammals of its size.  It seemingly does not age much in those 28 years either.  It remains “young, healthy and fully fertile for almost all its days, which for an elderly animal is equivalent to an 80-year-old woman having the biological make-up of someone 50 years younger.”  The naked mole rat is used in both cancer research and the study of aging.  Not only making it a bizarre creature, but an incredibly important creature as well.(Image credit: Buffenstein/Barshop institute/UTHSCSA) [...]

  4. [...] This creature has a lot of characteristics that make it very important to human beings.  For one it is resistant to cancer.  They also live up to 28 years, which is unheard of in mammals of its size.  It seemingly does not age much in those 28 years either.  It remains “young, healthy and fully fertile for almost all its days, which for an elderly animal is equivalent to an 80-year-old woman having the biological make-up of someone 50 years younger.”  The naked mole rat is used in both cancer research and the study of aging.  Not only making it a bizarre creature, but an incredibly important creature as well.(Image credit: Buffenstein/Barshop institute/UTHSCSA) [...]

  5. [...] #10. Naked Mole RatThe naked mole rat also known as the sand puppy or desert mole rat, is a burrowing rodent native to parts of East Africa and is the only species currently classified in the genus Heterocephalus. Naked mole rats have lifespans of over 30 years, more than 10 fold the lifespan of typical rodents.(source) [...]

  6. [...] pleasing to the eye — we’re looking at you, naked mole rat — every one of them has a special and important place on this beautiful planet called [...]

  7. [...] This creature has a lot of characteristics that make it very important to human beings.  For one it is resistant to cancer.  They also live up to 28 years, which is unheard of in mammals of its size.  It seemingly does not age much in those 28 years either.  It remains “young, healthy and fully fertile for almost all its days, which for an elderly animal is equivalent to an 80-year-old woman having the biological make-up of someone 50 years younger.”  The naked mole rat is used in both cancer research and the study of aging.  Not only making it a bizarre creature, but an incredibly important creature as well.(Image credit: Buffenstein/Barshop institute/UTHSCSA) [...]

  8. [...] Essa espécie de rato é conhecida por viver a vida inteira (ou maior parte dela), embaixo do solo, sendo , raramente vistos na superfície. A rainha do grupo acasala-se com um único macho, é ela quem comanda os outros membros do grupo, ela mantém o controle através dos feromônios que libera em sua urina, quando os outros entram em contato com a urina ficam suscetíveis a ela. (Créditos de Imagem: extremelongevity.net) [...]

  9. [...] This creature has a lot of characteristics that make it very important to human beings.  For one it is resistant to cancer.  They also live up to 28 years, which is unheard of in mammals of its size.  It seemingly does not age much in those 28 years either.  It remains “young, healthy and fully fertile for almost all its days, which for an elderly animal is equivalent to an 80-year-old woman having the biological make-up of someone 50 years younger.”  The naked mole rat is used in both cancer research and the study of aging.  Not only making it a bizarre creature, but an incredibly important creature as well.(Image credit: Buffenstein/Barshop institute/UTHSCSA) [...]

  10. [...] en.academic.ru | imgur forum.lowyat.net oregonzoo.org webecoist Michael Despines extremelongevity.net zoochat.com interactiveoceans.washington.edu animalsadda.com [...]

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