The family of Sirtuin genes has been linked to longevity.  Activating them generally appears to increase lifespan.  This has been demonstrated in several species, though there is some controversy about its degree of effect. Resveratrol is a small polyphenol molecule found in among other places, grapes.  There has been research suggesting that resveratrol activates the sirtuins but this too remains [...]

Scientists at the Salk institute have discovered that increasing expression of a gene called PCG1 in fruit flies reduced signs of aging. The effect was demonstrated in the lining of the insect’s intestine and mimicked the effects of caloric restriction. This gene is also found in humans. Caloric restriction is found to increase lifespan across multiple species including insects and mammals. [...]

Scientists at Emory School of Medicine have discovered a set of muscle genes in fruitfiles that appear to modulate aging. The group began investigating a gene called p38 kinase to see if it was involved in learning and memory.  They then discovered that mutations in these genes appeared to accelerate aging in the flies by making them more susceptible to oxidative stress.  Flies lacking the genes [...]

Scientists have identified an intracellular protein that acts as an antioxidant called Lon protease.  This protein was first described in 2002 and is believed to specifically prevent mitochondria from undergoing oxidative damage. In young cells when mitochondria are assaulted by oxidative stress, usually in the form of oxygen free radicals, they are able to increase production of Lon protease which [...]

Scientists have discovered that the enzyme angiotensin is present in mitochondria along with a receptor to which it attaches. Angiotensin is already of recognized importance in regulating blood pressure and multiple medications exist which manipulate the angiotensin system for the purpose of treating hypertension. In the present research it was discovered that mitochondrial angiotensin levels appear [...]